In cerebellar granule cells, neutrophils and PC12 cells, pinealon produced dose-dependent restriction of reactive oxygen species accumulation and reduced necrotic cell death.
Khavinson V et al., Rejuvenation Res 2011Free shipping over €250 · Tracked, discreet delivery in Europe
premium-grade research peptides
Pinealon10 mg
Lyophilized peptide · single vial
What it is
Pinealon is a synthetic tripeptide with the sequence Glu-Asp-Arg, also written EDR. It was derived from Cortexin, a brain polypeptide preparation, by the St Petersburg Institute of Bioregulation and Gerontology. It appears in neuroprotection and peptide bioregulation research.
- Class
- Neuropeptides
- Formula
- Pinealon · 10 mg
- Format
- Lyophilized powder
How it works
Pinealon is a synthetic tripeptide bioregulator (Glu-Asp-Arg), researched in early-stage models of neuroprotection and cognitive aging.
Bioregulator
A proposed gene signal
Pinealon belongs to a class of short peptides thought to influence gene expression in target tissues.
Neuro
Studied in neuron models
Early-stage research reports lower oxidative damage and cell-death markers in neuronal models exposed to pinealon.
Evidence
An early evidence base
The mechanism is not yet well established, and most findings come from preclinical and in-vitro research.
Key benefits
- Lyophilized powder, reconstituted for repeatable preparation.
- COA-verified identity and purity, batch by batch.
- Research-use plans built around a compound-specific question.
Laboratory research only. Not for human or veterinary use.
What published research is studying
Preclinical research- Reactive oxygen species accumulation in cultured rat cerebellar granule cells and PC12 cells
- Necrotic cell death and cell cycle progression in neuronal cultures
- Spatial orientation and learning in rat offspring after prenatal hyperhomocysteinemia
- Expression of genes and proteins linked to Alzheimer's disease pathology in cell models
The published evidence for pinealon is preclinical, drawn from rodent and cell culture models, with no randomized controlled trial in humans.
Key research findings and references
Key research findings
In rat offspring exposed to prenatal hyperhomocysteinemia, pinealon given to the pregnant dams improved spatial orientation and learning and lowered cerebellar neuron ROS accumulation.
Arutjunyan A et al., Int J Clin Exp Med 2012A review of EDR peptide work reports that it limits dendritic spine loss in neuronal cultures from mice modelling Alzheimer's and Huntington's disease.
Khavinson V et al., Molecules 2020Published study duration
- Cell viability experiments: single in-vitro exposures, with no in-vivo dosing period (Khavinson 2011).
- Prenatal hyperhomocysteinemia study: dosing across rat pregnancy, with offspring assessed after birth (Arutjunyan 2012).
Research endpoints
- Reactive oxygen species accumulation in cultured cells
- Necrotic cell death by propidium iodide staining
- ERK 1/2 activation time course and cell cycle distribution
- Spatial orientation and learning in rodent behavioural tests
- Antioxidant enzyme expression in cerebellar neuron culture
References
- Khavinson V et al., Rejuvenation Res 2011. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes
- Arutjunyan A et al., Int J Clin Exp Med 2012. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia
- Khavinson V et al., Molecules 2020. EDR peptide: possible mechanism of gene expression and protein synthesis regulation in the pathogenesis of Alzheimer's disease
Summaries of published research, for context only. Research use only. Not for human or veterinary use.
premium-grade research peptides
Pinealon10 mg
Choose your vial
Choose strength
Quantity
1 vial
Add 2 more, save 5%
1 × Pinealon · 10 mg€80 / vial
€80
Free1 × 3 ml bacteriostatic water · 10 × 0.5 ml syringes · 10 × alcohol swabs · uu.life research handling card
- €170 to free shipping
- Ships in 1-2 business days
- Discreet EU
What you get
- 1 × Pinealon · 10 mg
Medical supply kitFreeOne kit with every vial1 × 3 ml bacteriostatic water10 × 0.5 ml syringes10 × alcohol swabs- uu.life research handling card
One supply kit ships with every vial: the counts above follow the quantity.
Optional spare suppliesHow To Use The Vials
The standard supplies above ship free with every vial. Add extras only if the research plan needs more.
Independently lab tested
99%+ purity standard
Identity verified by LC-MS
Batch COA available
Tracked delivery to European Union
Research bundles
Explore research bundles
Curated pairs and blends this compound is studied alongside. Priced live from the catalogue.
Research pairFocus & Calm bundle
Semax + Selank
Two neuropeptides reviewed side by side: one studied for attention and cognition, the other for stress response.
Research handling
Full handling guide- 01
Lyophilized, sealed, batch-numbered
Each vial ships as a freeze-dried powder under an inert seal, tied to the batch on its Certificate of Analysis.
- 02
Store cold and dark
Unopened vials are kept refrigerated at 2-8°C away from light. Reconstituted material is stored refrigerated and used within the window the research plan defines.
- 03
Reconstitute with bacteriostatic water
The included bacteriostatic water is added slowly down the vial wall and the vial is swirled, never shaken.
- 04
Research use only
Supplied for laboratory research. Not for human or veterinary use. Handle with the personal protective equipment the laboratory requires.
Before you order
What ships in the box?
The vials selected, plus a free supply kit with every vial: one 3 ml bacteriostatic water, ten 0.5 ml syringes and ten alcohol swabs per vial, and the uu.life research handling card.
How does volume pricing work?
The price per vial depends on how many vials of the same strength are on the line. 3-4 vials take 5% off, 5 or more take 10% off. The discount is applied automatically and shows on the product page, in the cart and at checkout.
Is every batch tested?
Yes. Every batch is tested by an independent laboratory for identity and purity, and the Certificate of Analysis is linked from this page and the lab-testing library.
How fast is delivery?
Orders are typically dispatched within 1-2 business days and arrive across most of Europe in 3-5 business days, tracked, in discreet packaging. Orders over €250 ship free, and Shipping Protection can be added at checkout.
Is this for human use?
No. Every product is sold for laboratory research only and is not for human or veterinary use.
Ready to order Pinealon?
Choose a strength and quantity above. Volume pricing applies automatically.
Quality you can trace.
Batch-tested purity
Every vial ships with a Certificate of Analysis from an independent third-party lab. No exceptions.
Fast shipping
Orders are typically dispatched within 1-2 business days. Most European deliveries arrive in 3-5 business days.
Replacement guarantee
Arrived damaged? Send photos and the order number and a replacement is arranged.
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