In 30 patients in acute hemispheric ischemic stroke, against 80 matched controls, semax added to intensive therapy was associated with faster regression of focal, especially motor, deficits.
Gusev EI et al., Zh Nevrol Psikhiatr Im S S Korsakova 1997Free shipping over €250 · Tracked, discreet delivery in Europe
premium-grade research peptides
Semax10 mg
Synthetic ACTH analog. Cognitive enhancement premium-grade research peptide. Lyophilized powder for reconstitution.
Lyophilized peptide · single vial
What it is
Semax is a synthetic heptapeptide analogue of the ACTH(4-10) fragment, carrying a Pro-Gly-Pro tail that slows its breakdown and leaves it without corticotropic activity. It was developed in Russia, where it is registered for cerebrovascular indications, and it appears in stroke-recovery and cognition research. Most of its clinical record is Russian.
- Class
- Neuropeptides
- Formula
- Semax · 10 mg
- Format
- Lyophilized powder
How it works
Semax is a synthetic analog of an ACTH fragment, studied in cognitive and nootropic research.
ACTH
A neuropeptide fragment
Semax is based on a short ACTH fragment that carries no hormonal activity but retains effects on the nervous system.
BDNF
Raises growth factor signals
Research reports increased BDNF expression and dopamine signaling in brain regions linked to attention and memory.
Cognition
Studied under load
Semax is researched for attention and memory performance, including in models of fatigue and reduced blood flow.
Key benefits
- Focus research covering attention, clarity, and cognition.
- Protocols studying how the brain handles stress and recovery.
- Studied as a daytime nootropic option for sharper focus.
Laboratory research only. Not for human or veterinary use.
What published research is studying
Mixed evidence base- Recovery of neurological function in the acute period of hemispheric ischemic stroke
- Functional outcome measured by Barthel index at early and late stages of ischemic stroke
- Resting-state brain functional connectivity in healthy adults
- BDNF and TrkB expression and post-ischemic gene expression in rodent models
Clinical data come almost entirely from Russian stroke studies with small or historical control groups, and no Western randomised controlled trial has been completed.
Key research findings and references
Key research findings
In 110 patients studied across stages of ischemic stroke, semax with higher BDNF levels was associated with faster improvement and a better final Barthel index.
Gusev EI et al., Zh Nevrol Psikhiatr Im S S Korsakova 2018In 52 healthy participants assigned to semax, selank or placebo, resting-state fMRI showed group and condition differences in connectivity between the right amygdala and fusiform and temporal regions.
Panikratova YR et al., Dokl Biol Sci 2020In rats, tritium-labelled semax bound basal forebrain tissue specifically and reversibly with a KD of 2.4 nM, and intranasal administration raised BDNF protein within 3 hours.
Dolotov OV et al., J Neurochem 2006Published study duration
- Acute ischemic stroke study: courses of 5 days for moderate strokes and 10 days for severe strokes (Gusev et al. 1997).
- Stroke rehabilitation study: two 10-day courses separated by a 20-day interval, with 5 months of observation (Gusev et al. 2018).
- Rodent focal-ischemia transcriptome study: brain sampled at 3 hours and 24 hours after occlusion (Medvedeva et al. 2014).
Research endpoints
- Barthel index score
- Regression of focal and motor neurological deficit
- Serum BDNF level
- Resting-state functional connectivity of the amygdala
- Brain BDNF and TrkB expression in rodents
References
- Gusev EI et al., Zh Nevrol Psikhiatr Im S S Korsakova 1997. Effectiveness of semax in the acute period of hemispheric ischemic stroke
- Gusev EI et al., Zh Nevrol Psikhiatr Im S S Korsakova 2018. Efficacy of semax in patients at different stages of ischemic stroke
- Panikratova YR et al., Dokl Biol Sci 2020. Functional connectomic approach to studying selank and semax effects
- Dolotov OV et al., J Neurochem 2006. Semax binds specifically and increases BDNF protein in rat basal forebrain
- Medvedeva EV et al., BMC Genomics 2014. Semax affects immune and vascular gene expression in rat brain focal ischemia
- Dolotov OV et al., Brain Res 2006. Semax regulates BDNF and trkB expression in the rat hippocampus
Summaries of published research, for context only. Research use only. Not for human or veterinary use.
premium-grade research peptides
Semax10 mg
Synthetic ACTH analog. Cognitive enhancement premium-grade research peptide. Lyophilized powder for reconstitution.
Choose your vial
Choose strength
Quantity
1 vial
Add 2 more, save 5%
1 × Semax · 10 mg€55 / vial
€55
Free1 × 3 ml bacteriostatic water · 10 × 0.5 ml syringes · 10 × alcohol swabs · uu.life research handling card
- €195 to free shipping
- Ships in 1-2 business days
- Discreet EU
What you get
- 1 × Semax · 10 mg
Medical supply kitFreeOne kit with every vial1 × 3 ml bacteriostatic water10 × 0.5 ml syringes10 × alcohol swabs- uu.life research handling card
One supply kit ships with every vial: the counts above follow the quantity.
Optional spare suppliesHow To Use The Vials
The standard supplies above ship free with every vial. Add extras only if the research plan needs more.
Independently lab tested
99%+ purity standard
Identity verified by LC-MS
Batch COA available
Tracked delivery to European Union
Research bundles
Explore research bundles
Curated pairs and blends this compound is studied alongside. Priced live from the catalogue.
Research pairFocus & Calm bundle
Semax + Selank
Two neuropeptides reviewed side by side: one studied for attention and cognition, the other for stress response.
Research handling
Full handling guide- 01
Lyophilized, sealed, batch-numbered
Each vial ships as a freeze-dried powder under an inert seal, tied to the batch on its Certificate of Analysis.
- 02
Store cold and dark
Unopened vials are kept refrigerated at 2-8°C away from light. Reconstituted material is stored refrigerated and used within the window the research plan defines.
- 03
Reconstitute with bacteriostatic water
The included bacteriostatic water is added slowly down the vial wall and the vial is swirled, never shaken.
- 04
Research use only
Supplied for laboratory research. Not for human or veterinary use. Handle with the personal protective equipment the laboratory requires.
Before you order
What ships in the box?
The vials selected, plus a free supply kit with every vial: one 3 ml bacteriostatic water, ten 0.5 ml syringes and ten alcohol swabs per vial, and the uu.life research handling card.
How does volume pricing work?
The price per vial depends on how many vials of the same strength are on the line. 3-4 vials take 5% off, 5 or more take 10% off. The discount is applied automatically and shows on the product page, in the cart and at checkout.
Is every batch tested?
Yes. Every batch is tested by an independent laboratory for identity and purity, and the Certificate of Analysis is linked from this page and the lab-testing library.
How fast is delivery?
Orders are typically dispatched within 1-2 business days and arrive across most of Europe in 3-5 business days, tracked, in discreet packaging. Orders over €250 ship free, and Shipping Protection can be added at checkout.
Is this for human use?
No. Every product is sold for laboratory research only and is not for human or veterinary use.
Ready to order Semax?
Choose a strength and quantity above. Volume pricing applies automatically.
Quality you can trace.
Batch-tested purity
Every vial ships with a Certificate of Analysis from an independent third-party lab. No exceptions.
Fast shipping
Orders are typically dispatched within 1-2 business days. Most European deliveries arrive in 3-5 business days.
Replacement guarantee
Arrived damaged? Send photos and the order number and a replacement is arranged.
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