In diet-induced obese mice, small-molecule NNMT inhibitors reduced body weight, white adipose mass, adipocyte size, and plasma cholesterol, with no change in total food intake.
Neelakantan H et al., Biochem Pharmacol 2018Free shipping over €250 · Tracked, discreet delivery in Europe
premium-grade research peptides
5 Amino 1MQ5 mg
Lyophilized peptide · single vial
What it is
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small molecule, not a peptide. It is a membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme concentrated in white adipose tissue and skeletal muscle. It appears in preclinical metabolic, adipose, and muscle-ageing research.
- Class
- GLP-1 & Metabolic
- Formula
- 5 Amino 1MQ · 5 mg
- Format
- Lyophilized powder
How it works
5-Amino-1MQ is a small-molecule inhibitor of the NNMT enzyme, researched in metabolism and body composition studies.
NNMT
Blocks the NNMT enzyme
5-Amino-1MQ inhibits nicotinamide N-methyltransferase, an enzyme linked to cellular energy regulation and fat storage.
NAD+
Spares the NAD+ pool
By inhibiting NNMT, the compound is studied for preserving nicotinamide, a precursor cells use to make NAD+.
Metabolic
Studied in fat tissue
Preclinical research reports reduced fat mass in diet-induced obesity models treated with NNMT inhibitors.
Key benefits
- Lyophilized powder, reconstituted for repeatable preparation.
- COA-verified identity and purity, batch by batch.
- Research-use plans built around a compound-specific question.
Laboratory research only. Not for human or veterinary use.
What published research is studying
Preclinical research- Body weight, fat mass, and adipocyte size in diet-induced obese mice
- Glucose tolerance, insulin sensitivity, and hepatic steatosis in rodent models
- Muscle stem cell activity, grip strength, and regeneration in aged mice
- NAD+ and methyl-donor metabolism in cultured adipocytes
All published efficacy data come from rodent and cell-culture studies. No completed human trial of 5-amino-1MQ has been published.
Key research findings and references
Key research findings
In diet-induced obese mice given 5-amino-1MQ over 28 days, gains in body weight and fat mass fell dose-dependently, with improved oral glucose tolerance.
Babula JJ et al., Diabetes Obes Metab 2024In 24-month-old mice, an NNMT inhibitor was associated with roughly 40% greater grip strength than sedentary controls, and roughly 60% when paired with exercise.
Dimet-Wiley AL et al., Sci Rep 2024In aged mice after muscle injury, an NNMT inhibitor was reported to nearly double myofiber cross-sectional area and raise peak tibialis anterior torque by about 70% versus controls.
Neelakantan H et al., Biochem Pharmacol 2019Published study duration
- Diet-induced obesity study in mice: 28 days of dosing (Babula et al. 2024).
- Aged-mouse muscle function study: dosing from 22 to 24 months of age (Dimet-Wiley et al. 2024).
- Muscle regeneration study: 1 to 3 weeks of dosing after injury in 24-month-old mice (Neelakantan et al. 2019).
Research endpoints
- Body weight and fat mass gain in rodents
- White adipose mass and adipocyte size
- Oral glucose tolerance and fasting insulin
- Hepatic triglyceride content and transaminase levels
- Grip strength, peak torque, and myofiber cross-sectional area
References
- Neelakantan H et al., Biochem Pharmacol 2018. Selective and membrane-permeable small molecule inhibitors of NNMT reverse high fat diet-induced obesity in mice
- Babula JJ et al., Diabetes Obes Metab 2024. Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction
- Dimet-Wiley AL et al., Sci Rep 2024. NNMT inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice
- Neelakantan H et al., Biochem Pharmacol 2019. Small molecule NNMT inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle
- Dimet-Wiley A et al., Sci Rep 2022. Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice
Summaries of published research, for context only. Research use only. Not for human or veterinary use.
premium-grade research peptides
5 Amino 1MQ5 mg
Choose your vial
Choose strength
Quantity
1 vial
Add 2 more, save 5%
1 × 5 Amino 1MQ · 5 mg€49 / vial
€49
Free1 × 3 ml bacteriostatic water · 10 × 0.5 ml syringes · 10 × alcohol swabs · uu.life research handling card
- €201 to free shipping
- Ships in 1-2 business days
- Discreet EU
What you get
- 1 × 5 Amino 1MQ · 5 mg
Medical supply kitFreeOne kit with every vial1 × 3 ml bacteriostatic water10 × 0.5 ml syringes10 × alcohol swabs- uu.life research handling card
One supply kit ships with every vial: the counts above follow the quantity.
Optional spare suppliesHow To Use The Vials
The standard supplies above ship free with every vial. Add extras only if the research plan needs more.
Independently lab tested
99%+ purity standard
Identity verified by LC-MS
Batch COA available
Tracked delivery to European Union
Research bundles
Explore research bundles
Curated pairs and blends this compound is studied alongside. Priced live from the catalogue.
Research pairLean & Glow bundle
Retatrutide + GHK-Cu
Weight research paired with skin research. A triple-receptor peptide studied for weight reduction, next to a copper peptide studied for collagen support.
- Includes
- Retatrutide€99
- GHK-Cu€49
Research handling
Full handling guide- 01
Lyophilized, sealed, batch-numbered
Each vial ships as a freeze-dried powder under an inert seal, tied to the batch on its Certificate of Analysis.
- 02
Store cold and dark
Unopened vials are kept refrigerated at 2-8°C away from light. Reconstituted material is stored refrigerated and used within the window the research plan defines.
- 03
Reconstitute with bacteriostatic water
The included bacteriostatic water is added slowly down the vial wall and the vial is swirled, never shaken.
- 04
Research use only
Supplied for laboratory research. Not for human or veterinary use. Handle with the personal protective equipment the laboratory requires.
Before you order
What ships in the box?
The vials selected, plus a free supply kit with every vial: one 3 ml bacteriostatic water, ten 0.5 ml syringes and ten alcohol swabs per vial, and the uu.life research handling card.
How does volume pricing work?
The price per vial depends on how many vials of the same strength are on the line. 3-4 vials take 5% off, 5 or more take 10% off. The discount is applied automatically and shows on the product page, in the cart and at checkout.
Is every batch tested?
Yes. Every batch is tested by an independent laboratory for identity and purity, and the Certificate of Analysis is linked from this page and the lab-testing library.
How fast is delivery?
Orders are typically dispatched within 1-2 business days and arrive across most of Europe in 3-5 business days, tracked, in discreet packaging. Orders over €250 ship free, and Shipping Protection can be added at checkout.
Is this for human use?
No. Every product is sold for laboratory research only and is not for human or veterinary use.
Ready to order 5 Amino 1MQ?
Choose a strength and quantity above. Volume pricing applies automatically.
Quality you can trace.
Batch-tested purity
Every vial ships with a Certificate of Analysis from an independent third-party lab. No exceptions.
Fast shipping
Orders are typically dispatched within 1-2 business days. Most European deliveries arrive in 3-5 business days.
Replacement guarantee
Arrived damaged? Send photos and the order number and a replacement is arranged.
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