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Retatrutide10 mg

The triple-agonist studied for major weight reduction. GLP-1 / GIP / Glucagon receptor triple agonist peptide, lyophilized for reconstitution.

What it is

Retatrutide (LY3437943) is a synthetic single-chain peptide that activates three receptors at once: GLP-1, GIP, and glucagon. It was developed by Eli Lilly and is described in the literature as a triple hormone-receptor agonist. It appears in obesity, type 2 diabetes, and fatty liver research, and has reached randomised Phase 2 trials.

Class
GLP-1 & Metabolic
Formula
Retatrutide · 10 mg
Format
Lyophilized powder

How it works

Retatrutide is a triple receptor agonist studied for major weight reduction in clinical research.

Triple

Three receptors at once

Retatrutide activates GLP-1, GIP and glucagon receptors within a single molecule.

Appetite

Signals through incretins

GLP-1 and GIP activation acts on appetite and insulin pathways, studied for reduced food intake.

Glucagon

Adds energy expenditure

The glucagon component is thought to raise energy expenditure, a third lever beyond appetite alone.

Key benefits

  • Weight-management research focused on appetite and body-fat reduction.
  • Metabolic protocols looking at blood sugar and energy balance.
  • Compared with single- and dual-agonist GLP-1 peptides for stronger effect.

Laboratory research only. Not for human or veterinary use.

What published research is studying

Early human data
  • Weight reduction in adults with obesity or overweight (Phase 2)
  • Glycaemic control and body weight in adults with type 2 diabetes (Phase 2)
  • Liver fat in metabolic dysfunction-associated steatotic liver disease (Phase 2a substudy)
  • Gastrointestinal tolerability across escalating trial arms

Human evidence is at the Phase 2 stage: randomised and placebo-controlled, but without published Phase 3 or long-term outcome results.

Key research findings and references

Key research findings

In a 36-week Phase 2 trial in 281 adults with type 2 diabetes, HbA1c fell 2.02% at 24 weeks in the 12 mg group, against 0.01% with placebo.

Rosenstock J et al., Lancet 2023

In a Phase 2a substudy of 98 participants with liver fat of at least 10%, mean liver fat fell 82.4% at 24 weeks in the 12 mg group.

Sanyal AJ et al., Nat Med 2024

Published study duration

  • Phase 2 obesity trial: 48 weeks (NCT04881760).
  • Phase 2 type 2 diabetes trial: 36 weeks, with the primary glycaemic readout at 24 weeks (NCT04867785).
  • Liver fat substudy readout: 24 weeks within the 48-week obesity trial.

Research endpoints

  • Percent change in body weight
  • Proportion reaching 5%, 10%, or 15% weight reduction
  • Change in HbA1c from baseline
  • Liver fat content by MRI
  • Gastrointestinal adverse events and discontinuation

References

  1. Jastreboff AM et al., N Engl J Med 2023. Triple-Hormone-Receptor Agonist Retatrutide for Obesity, A Phase 2 Trial
  2. Rosenstock J et al., Lancet 2023. Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes
  3. Sanyal AJ et al., Nat Med 2024. Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease
  4. ClinicalTrials.gov NCT04881760. Phase 2 study of once-weekly LY3437943 in participants with obesity or overweight

Summaries of published research, for context only. Research use only. Not for human or veterinary use.

premium-grade research peptides

Retatrutide10 mg

The triple-agonist studied for major weight reduction. GLP-1 / GIP / Glucagon receptor triple agonist peptide, lyophilized for reconstitution.

Choose your vial

Choose strength
Quantity
1 vial

Add 2 more, save 5%

1 × Retatrutide · 10 mg€99 / vial
€99

Free1 × 3 ml bacteriostatic water · 10 × 0.5 ml syringes · 10 × alcohol swabs · uu.life research handling card

  • €151 to free shipping
  • Ships in 1-2 business days
  • Discreet EU

What you get

  • 1 × Retatrutide · 10 mg
  • Medical supply kitFreeOne kit with every vial1 × 3 ml bacteriostatic water10 × 0.5 ml syringes10 × alcohol swabs
  • uu.life research handling card

One supply kit ships with every vial: the counts above follow the quantity.

Optional spare suppliesHow To Use The Vials

The standard supplies above ship free with every vial. Add extras only if the research plan needs more.

Independently lab tested
99%+ purity standard
Identity verified by LC-MS
Batch COA available
Tracked delivery to European Union

Research bundles

Explore research bundles

Curated pairs and blends this compound is studied alongside. Priced live from the catalogue.

Research handling

Full handling guide
  1. 01

    Lyophilized, sealed, batch-numbered

    Each vial ships as a freeze-dried powder under an inert seal, tied to the batch on its Certificate of Analysis.

  2. 02

    Store cold and dark

    Unopened vials are kept refrigerated at 2-8°C away from light. Reconstituted material is stored refrigerated and used within the window the research plan defines.

  3. 03

    Reconstitute with bacteriostatic water

    The included bacteriostatic water is added slowly down the vial wall and the vial is swirled, never shaken.

  4. 04

    Research use only

    Supplied for laboratory research. Not for human or veterinary use. Handle with the personal protective equipment the laboratory requires.

Before you order

What ships in the box?

The vials selected, plus a free supply kit with every vial: one 3 ml bacteriostatic water, ten 0.5 ml syringes and ten alcohol swabs per vial, and the uu.life research handling card.

How does volume pricing work?

The price per vial depends on how many vials of the same strength are on the line. 3-4 vials take 5% off, 5 or more take 10% off. The discount is applied automatically and shows on the product page, in the cart and at checkout.

Is every batch tested?

Yes. Every batch is tested by an independent laboratory for identity and purity, and the Certificate of Analysis is linked from this page and the lab-testing library.

How fast is delivery?

Orders are typically dispatched within 1-2 business days and arrive across most of Europe in 3-5 business days, tracked, in discreet packaging. Orders over €250 ship free, and Shipping Protection can be added at checkout.

Is this for human use?

No. Every product is sold for laboratory research only and is not for human or veterinary use.

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Choose a strength and quantity above. Volume pricing applies automatically.

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Quality you can trace.

Batch-tested purity

Every vial ships with a Certificate of Analysis from an independent third-party lab. No exceptions.

Fast shipping

Orders are typically dispatched within 1-2 business days. Most European deliveries arrive in 3-5 business days.

Replacement guarantee

Arrived damaged? Send photos and the order number and a replacement is arranged.

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