In conscious swine, ipamorelin released growth hormone with potency similar to GHRP-6. It did not raise ACTH or cortisol above the levels seen after GHRH, even far above its ED50.
Raun K et al., Eur J Endocrinol 1998Free shipping over €250 · Tracked, discreet delivery in Europe
premium-grade research peptides
Ipamorelin10 mg
Lyophilized peptide · single vial
What it is
Ipamorelin is a synthetic pentapeptide, Aib-His-D-2-Nal-D-Phe-Lys-NH2, developed at Novo Nordisk from the growth hormone releasing peptide series. It acts at the ghrelin receptor and was described as the first growth hormone secretagogue selective for growth hormone release. It has been researched in endocrinology and, later, in gastrointestinal motility.
- Class
- Growth Hormone Secretagogues
- Formula
- Ipamorelin · 10 mg
- Format
- Lyophilized powder
How it works
Ipamorelin is a selective growth hormone secretagogue studied for GH release with minimal off-target effects.
GHS-R
Binds the ghrelin receptor
Ipamorelin acts on the growth hormone secretagogue receptor, the same receptor the hormone ghrelin signals through.
Selective
A narrow signal
Unlike earlier secretagogues, ipamorelin is studied for releasing growth hormone without meaningfully raising cortisol or prolactin.
Pulsatile
Keeps the natural rhythm
Research frames ipamorelin as preserving the pituitary's pulsatile release pattern rather than overriding it.
Key benefits
- Lyophilized powder, reconstituted for repeatable preparation.
- COA-verified identity and purity, batch by batch.
- Research-use plans built around a compound-specific question.
Laboratory research only. Not for human or veterinary use.
What published research is studying
Early human data- Selectivity of growth hormone release relative to ACTH, cortisol, prolactin, LH, FSH and TSH
- Pharmacokinetics and the shape of the growth hormone response in healthy volunteers
- Recovery of gut motility after bowel resection (phase 2 postoperative ileus trial)
- Longitudinal bone growth and bone mineral content in rodent models
Human data amount to one pharmacokinetic study in healthy volunteers and one phase 2 trial that missed its efficacy endpoint. The rest is animal work.
Key research findings and references
Key research findings
In healthy male volunteers studied at five escalating 15-minute infusion rates, kinetics were dose-proportional and the terminal half-life was about 2 hours. Growth hormone peaked once, at roughly 0.67 hours.
Gobburu JV et al., Pharm Res 1999In a double-blind phase 2 trial in 114 adults after bowel resection, median time to a first tolerated solid meal was 25.3 hours versus 32.6 hours on placebo. The difference was not statistically significant (p = 0.15).
Beck DE, Sweeney WB, McCarter MD, Int J Colorectal Dis 2014In adult female rats dosed for 15 days, longitudinal tibial growth rate rose dose-dependently from 42 to 52 micrometres per day. Total IGF-I and bone turnover markers were unchanged.
Johansen PB et al., Growth Horm IGF Res 1999Published study duration
- Phase 2 postoperative ileus trial: dosing from postoperative day 1 to day 7 or hospital discharge (NCT00672074).
- Rat longitudinal bone growth study: 15 days of dosing with tetracycline labelling on days 0, 6 and 13 (Johansen 1999).
- Rat bone mineral content study: 12 weeks of continuous subcutaneous infusion in 13-week-old females (Svensson 2000).
Research endpoints
- Peak plasma growth hormone, ED50 and Emax
- Plasma ACTH, cortisol, prolactin, LH, FSH and TSH as selectivity measures
- Terminal half-life, clearance and volume of distribution
- Time from first dose to tolerance of a standardised solid meal
- Longitudinal bone growth rate and bone mineral content by DXA
References
- Raun K et al., Eur J Endocrinol 1998. Ipamorelin, the first selective growth hormone secretagogue
- Gobburu JV et al., Pharm Res 1999. PK/PD modelling of ipamorelin in human volunteers
- Beck DE, Sweeney WB, McCarter MD, Int J Colorectal Dis 2014. Ipamorelin for postoperative ileus in bowel resection patients
- ClinicalTrials.gov NCT00672074. Safety and Efficacy of Ipamorelin for Management of Post-Operative Ileus
- Johansen PB et al., Growth Horm IGF Res 1999. Ipamorelin induces longitudinal bone growth in rats
- Svensson J et al., J Endocrinol 2000. Ipamorelin and GHRP-6 increase bone mineral content in adult female rats
Summaries of published research, for context only. Research use only. Not for human or veterinary use.
premium-grade research peptides
Ipamorelin10 mg
Choose your vial
Choose strength
Quantity
1 vial
Add 2 more, save 5%
1 × Ipamorelin · 10 mg€65 / vial
€65
Free1 × 3 ml bacteriostatic water · 10 × 0.5 ml syringes · 10 × alcohol swabs · uu.life research handling card
- €185 to free shipping
- Ships in 1-2 business days
- Discreet EU
What you get
- 1 × Ipamorelin · 10 mg
Medical supply kitFreeOne kit with every vial1 × 3 ml bacteriostatic water10 × 0.5 ml syringes10 × alcohol swabs- uu.life research handling card
One supply kit ships with every vial: the counts above follow the quantity.
Optional spare suppliesHow To Use The Vials
The standard supplies above ship free with every vial. Add extras only if the research plan needs more.
Independently lab tested
99%+ purity standard
Identity verified by LC-MS
Batch COA available
Tracked delivery to European Union
Research bundles
Explore research bundles
Curated pairs and blends this compound is studied alongside. Priced live from the catalogue.
Single-vial blend5mg CJC-1295 (w/o DAC) + 5mg Ipamorelin
CJC - No DAC + Ipamorelin
- Includes
- CJC - No DAC€80
- Ipamorelin€65
Research handling
Full handling guide- 01
Lyophilized, sealed, batch-numbered
Each vial ships as a freeze-dried powder under an inert seal, tied to the batch on its Certificate of Analysis.
- 02
Store cold and dark
Unopened vials are kept refrigerated at 2-8°C away from light. Reconstituted material is stored refrigerated and used within the window the research plan defines.
- 03
Reconstitute with bacteriostatic water
The included bacteriostatic water is added slowly down the vial wall and the vial is swirled, never shaken.
- 04
Research use only
Supplied for laboratory research. Not for human or veterinary use. Handle with the personal protective equipment the laboratory requires.
Before you order
What ships in the box?
The vials selected, plus a free supply kit with every vial: one 3 ml bacteriostatic water, ten 0.5 ml syringes and ten alcohol swabs per vial, and the uu.life research handling card.
How does volume pricing work?
The price per vial depends on how many vials of the same strength are on the line. 3-4 vials take 5% off, 5 or more take 10% off. The discount is applied automatically and shows on the product page, in the cart and at checkout.
Is every batch tested?
Yes. Every batch is tested by an independent laboratory for identity and purity, and the Certificate of Analysis is linked from this page and the lab-testing library.
How fast is delivery?
Orders are typically dispatched within 1-2 business days and arrive across most of Europe in 3-5 business days, tracked, in discreet packaging. Orders over €250 ship free, and Shipping Protection can be added at checkout.
Is this for human use?
No. Every product is sold for laboratory research only and is not for human or veterinary use.
Ready to order Ipamorelin?
Choose a strength and quantity above. Volume pricing applies automatically.
Quality you can trace.
Batch-tested purity
Every vial ships with a Certificate of Analysis from an independent third-party lab. No exceptions.
Fast shipping
Orders are typically dispatched within 1-2 business days. Most European deliveries arrive in 3-5 business days.
Replacement guarantee
Arrived damaged? Send photos and the order number and a replacement is arranged.
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