In mice, MOTS-c administration reduced diet-induced obesity and insulin resistance, alongside AMPK activation in skeletal muscle.
Lee C et al., Cell Metab 2015Free shipping over €250 · Tracked, discreet delivery in Europe
premium-grade research peptides
MOTS-C40 mg
Mitochondrial Open Reading Frame of the 12S rRNA-c. Lyophilized powder for reconstitution.
Lyophilized peptide · single vial
What it is
MOTS-c is a 16-amino-acid peptide encoded inside the mitochondrial 12S rRNA gene, one of the mitochondrial-derived peptides. It is produced by the body and can also be made synthetically. It appears in research on metabolism, skeletal muscle, exercise physiology, and ageing.
- Class
- GLP-1 & Metabolic
- Formula
- MOTS-C · 40 mg
- Format
- Lyophilized powder
How it works
MOTS-c is a mitochondrial-derived peptide encoded in the 12S rRNA gene, studied in metabolic research.
Mito
Made by mitochondria
Unlike most peptides, MOTS-c is encoded in mitochondrial DNA, placing it in a small class of mitochondrial-derived peptides.
AMPK
Activates the fuel sensor
MOTS-c is studied for activating AMPK, the cell's central energy-sensing pathway.
Metabolic
Follows exercise signals
MOTS-c levels rise with exercise in research models, and the peptide is studied for insulin sensitivity and metabolic flexibility.
Key benefits
- Metabolic research focused on energy production and insulin sensitivity.
- Weight-and-metabolic protocols studying cellular energy use.
- Studied as a metabolic-support option that works at the cellular level.
Laboratory research only. Not for human or veterinary use.
What published research is studying
Preclinical research- Insulin sensitivity and diet-induced obesity in rodent models
- Skeletal muscle metabolism and physical capacity in ageing mice
- The rise in endogenous MOTS-c in human skeletal muscle and blood after exercise
- Associations between circulating MOTS-c and body fat distribution in humans
No published randomised trial has given MOTS-c to humans. The human data are observational and measure the body's own MOTS-c levels, while all dosing results come from mice.
Key research findings and references
Key research findings
In mice aged 2, 12, and 22 months, MOTS-c administration improved physical performance, and intermittent dosing begun at 23.5 months increased physical capacity.
Reynolds JC et al., Nat Commun 2021In the same paper, exercise in human volunteers raised endogenous MOTS-c expression in skeletal muscle and in circulation.
Reynolds JC et al., Nat Commun 2021In a randomised 16-week aerobic and resistance exercise trial in 49 breast cancer survivors, plasma MOTS-c rose significantly in non-Hispanic White participants but not in Hispanic participants.
Dieli-Conwright CM et al., Sci Rep 2021Published study duration
- Exercise trial measuring endogenous MOTS-c in survivors of breast cancer: 16 weeks.
- Late-life mouse study: intermittent dosing 3 times weekly, begun at 23.5 months of age (Reynolds et al. 2021).
- Cross-sectional human study of plasma MOTS-c: single timepoint in 125 adults without diabetes (Sequeira et al. 2021).
Research endpoints
- Plasma MOTS-c concentration
- Whole-body insulin sensitivity by glucose infusion rate in mice
- Body weight and fat mass in rodent models
- Running and physical performance measures in mice
- Body fat distribution by DXA and magnetic resonance imaging
References
- Lee C et al., Cell Metab 2015. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
- Reynolds JC et al., Nat Commun 2021. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
- Dieli-Conwright CM et al., Sci Rep 2021. Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in breast cancer survivors
- Sequeira IR et al., Biochim Biophys Acta Gen Subj 2021. Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat
Summaries of published research, for context only. Research use only. Not for human or veterinary use.
premium-grade research peptides
MOTS-C40 mg
Mitochondrial Open Reading Frame of the 12S rRNA-c. Lyophilized powder for reconstitution.
Choose your vial
Choose strength
Quantity
1 vial
Add 2 more, save 5%
1 × MOTS-C · 40 mg€185 / vial
€185
Free1 × 3 ml bacteriostatic water · 10 × 0.5 ml syringes · 10 × alcohol swabs · uu.life research handling card
- €65 to free shipping
- Ships in 1-2 business days
- Discreet EU
What you get
- 1 × MOTS-C · 40 mg
Medical supply kitFreeOne kit with every vial1 × 3 ml bacteriostatic water10 × 0.5 ml syringes10 × alcohol swabs- uu.life research handling card
One supply kit ships with every vial: the counts above follow the quantity.
Optional spare suppliesHow To Use The Vials
The standard supplies above ship free with every vial. Add extras only if the research plan needs more.
Independently lab tested
99%+ purity standard
Identity verified by LC-MS
Batch COA available
Tracked delivery to European Union
Research bundles
Explore research bundles
Curated pairs and blends this compound is studied alongside. Priced live from the catalogue.
Research pairLean & Glow bundle
Retatrutide + GHK-Cu
Weight research paired with skin research. A triple-receptor peptide studied for weight reduction, next to a copper peptide studied for collagen support.
- Includes
- Retatrutide€99
- GHK-Cu€49
Research handling
Full handling guide- 01
Lyophilized, sealed, batch-numbered
Each vial ships as a freeze-dried powder under an inert seal, tied to the batch on its Certificate of Analysis.
- 02
Store cold and dark
Unopened vials are kept refrigerated at 2-8°C away from light. Reconstituted material is stored refrigerated and used within the window the research plan defines.
- 03
Reconstitute with bacteriostatic water
The included bacteriostatic water is added slowly down the vial wall and the vial is swirled, never shaken.
- 04
Research use only
Supplied for laboratory research. Not for human or veterinary use. Handle with the personal protective equipment the laboratory requires.
Before you order
What ships in the box?
The vials selected, plus a free supply kit with every vial: one 3 ml bacteriostatic water, ten 0.5 ml syringes and ten alcohol swabs per vial, and the uu.life research handling card.
How does volume pricing work?
The price per vial depends on how many vials of the same strength are on the line. 3-4 vials take 5% off, 5 or more take 10% off. The discount is applied automatically and shows on the product page, in the cart and at checkout.
Is every batch tested?
Yes. Every batch is tested by an independent laboratory for identity and purity, and the Certificate of Analysis is linked from this page and the lab-testing library.
How fast is delivery?
Orders are typically dispatched within 1-2 business days and arrive across most of Europe in 3-5 business days, tracked, in discreet packaging. Orders over €250 ship free, and Shipping Protection can be added at checkout.
Is this for human use?
No. Every product is sold for laboratory research only and is not for human or veterinary use.
Ready to order MOTS-C?
Choose a strength and quantity above. Volume pricing applies automatically.
Quality you can trace.
Batch-tested purity
Every vial ships with a Certificate of Analysis from an independent third-party lab. No exceptions.
Fast shipping
Orders are typically dispatched within 1-2 business days. Most European deliveries arrive in 3-5 business days.
Replacement guarantee
Arrived damaged? Send photos and the order number and a replacement is arranged.
You may also research.
Most ordered. The most ordered research line over the last 90 days.GLP-1 & MetabolicRetatrutideTriple agonist€99/ vial1
Best seller. Among the most ordered research lines over the last 90 days.GLP-1 & MetabolicTirzepatide (GLP-2)Dual agonist€70/ vial1
Best seller. Among the most ordered research lines over the last 90 days.GLP-1 & MetabolicTesamorelinVisceral fat10 mg€95/ vial1
GLP-1 & Metabolic5 Amino 1MQNNMT · metabolism5 mg€49/ vial1