In telomerase-negative human fetal fibroblast culture, Epithalon induced expression of the telomerase catalytic subunit, telomerase activity and telomere elongation.
Khavinson VKh et al., Bull Exp Biol Med 2003Free shipping over €250 · Tracked, discreet delivery in Europe
premium-grade research peptides
Epithalon5 mg
Synthetic pineal tetrapeptide. Telomerase activator studied for cellular aging, premium-grade research peptide. Lyophilized powder for reconstitution.
Lyophilized peptide · single vial
What it is
Epithalon, also written epitalon, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. It was derived from Epithalamin, a pineal gland peptide preparation developed in St Petersburg. It appears in gerontology and telomere biology research.
- Class
- Beauty & Longevity
- Formula
- Epithalon · 5 mg
- Format
- Lyophilized powder
How it works
Epithalon is a synthetic four-amino-acid version of a pineal peptide, studied in early-stage telomerase and aging research.
Pineal
Based on epithalamin
Epithalon reproduces the active core of epithalamin, a peptide extract of the pineal gland studied in aging research.
Telomerase
A proposed telomere link
Early-stage research reports telomerase activation in some cell models, a proposed pathway that is not fully established.
Evidence
Still an open question
Most findings come from preclinical and small human studies, so the mechanism is framed as provisional.
Key benefits
- Longevity research focused on telomere biology and cellular aging.
- Bioregulation protocols studying how the body maintains itself over time.
- Short, cyclical research patterns rather than continuous daily use.
Laboratory research only. Not for human or veterinary use.
What published research is studying
Preclinical research- Telomerase activity and telomere length in cultured human somatic cells
- The division limit of human fetal fibroblast cultures
- Life span, chromosome aberrations and tumour incidence in mice
- Mortality and cardiovascular ageing in elderly cohorts given the Epithalamin preparation
Human data on the synthetic tetrapeptide itself are minimal; the longevity figures come from non-blinded cohorts given the Epithalamin preparation, reported almost entirely by one research group.
Key research findings and references
Key research findings
In female SHR mice given Epitalon from 3 months of age, mean life span was unchanged, while maximum life span rose 12.3% and leukaemia incidence fell 6-fold.
Anisimov VN et al., Biogerontology 2003In a 6-8 year observation of 266 elderly people, the group given the pineal preparation Epithalamin had a 1.6 to 1.8-fold lower mortality rate than controls.
Khavinson VKh and Morozov VG, Neuro Endocrinol Lett 2003In a 12-year randomized study in elderly people with coronary disease, cardiovascular mortality was 2-fold lower in the Epithalamin group than in the control group.
Korkushko OV et al., Bull Exp Biol Med 2006Published study duration
- Mouse life span study: monthly 5-day courses from 3 months of age until natural death (Anisimov 2003).
- Elderly cohort observation: 6-8 years, with the peptide preparations applied over the first 2-3 years (Khavinson and Morozov 2003).
- Randomized elderly coronary disease study: 12 years of follow-up (Korkushko 2006).
Research endpoints
- Telomerase catalytic subunit expression and enzyme activity
- Telomere length in fibroblast culture
- Mean and maximum life span in mice
- All-cause and cardiovascular mortality
- Chromosome aberration frequency in bone marrow cells
References
- Khavinson VKh et al., Bull Exp Biol Med 2003. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
- Khavinson VKh et al., Bull Exp Biol Med 2004. Peptide promotes overcoming of the division limit in human somatic cell
- Anisimov VN et al., Biogerontology 2003. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in SHR mice
- Khavinson VKh and Morozov VG, Neuro Endocrinol Lett 2003. Peptides of pineal gland and thymus prolong human life
- Korkushko OV et al., Bull Exp Biol Med 2006. Geroprotective effect of epithalamine in elderly subjects with accelerated aging
- Khavinson V et al., Neuro Endocrinol Lett 2002. Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa
Summaries of published research, for context only. Research use only. Not for human or veterinary use.
premium-grade research peptides
Epithalon5 mg
Synthetic pineal tetrapeptide. Telomerase activator studied for cellular aging, premium-grade research peptide. Lyophilized powder for reconstitution.
Choose your vial
Choose strength
Quantity
1 vial
1 × Epithalon · 5 mg€55 / vial
€55
Free1 × 3 ml bacteriostatic water · 10 × 0.5 ml syringes · 10 × alcohol swabs · uu.life research handling card
- €195 to free shipping
- Ships in 1-2 business days
- Discreet EU
What you get
- 1 × Epithalon · 5 mg
Medical supply kitFreeOne kit with every vial1 × 3 ml bacteriostatic water10 × 0.5 ml syringes10 × alcohol swabs- uu.life research handling card
One supply kit ships with every vial: the counts above follow the quantity.
Optional spare suppliesHow To Use The Vials
The standard supplies above ship free with every vial. Add extras only if the research plan needs more.
Independently lab tested
99%+ purity standard
Identity verified by LC-MS
Batch COA available
Tracked delivery to European Union
Research bundles
Explore research bundles
Curated pairs and blends this compound is studied alongside. Priced live from the catalogue.
Research pairLongevity bundle
NAD+ + Epithalon
Cellular energy research next to aging-model research. Two of the most cited longevity compounds, in one order.
Research handling
Full handling guide- 01
Lyophilized, sealed, batch-numbered
Each vial ships as a freeze-dried powder under an inert seal, tied to the batch on its Certificate of Analysis.
- 02
Store cold and dark
Unopened vials are kept refrigerated at 2-8°C away from light. Reconstituted material is stored refrigerated and used within the window the research plan defines.
- 03
Reconstitute with bacteriostatic water
The included bacteriostatic water is added slowly down the vial wall and the vial is swirled, never shaken.
- 04
Research use only
Supplied for laboratory research. Not for human or veterinary use. Handle with the personal protective equipment the laboratory requires.
Before you order
What ships in the box?
The vials selected, plus a free supply kit with every vial: one 3 ml bacteriostatic water, ten 0.5 ml syringes and ten alcohol swabs per vial, and the uu.life research handling card.
How does volume pricing work?
The price per vial depends on how many vials of the same strength are on the line. 3-4 vials take 5% off, 5 or more take 10% off. The discount is applied automatically and shows on the product page, in the cart and at checkout.
Is every batch tested?
Yes. Every batch is tested by an independent laboratory for identity and purity, and the Certificate of Analysis is linked from this page and the lab-testing library.
How fast is delivery?
Orders are typically dispatched within 1-2 business days and arrive across most of Europe in 3-5 business days, tracked, in discreet packaging. Orders over €250 ship free, and Shipping Protection can be added at checkout.
Is this for human use?
No. Every product is sold for laboratory research only and is not for human or veterinary use.
Ready to order Epithalon?
Choose a strength and quantity above. Volume pricing applies automatically.
Quality you can trace.
Batch-tested purity
Every vial ships with a Certificate of Analysis from an independent third-party lab. No exceptions.
Fast shipping
Orders are typically dispatched within 1-2 business days. Most European deliveries arrive in 3-5 business days.
Replacement guarantee
Arrived damaged? Send photos and the order number and a replacement is arranged.
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