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NAD+500 mg

Essential cellular coenzyme, studied for cellular aging. Research compound.

What it is

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every human cell. It carries electrons in redox reactions and is consumed as a substrate by sirtuins, PARP enzymes and CD38. Tissue levels decline with age, which is why it appears in metabolic and ageing research.

Class
Beauty & Longevity
Formula
NAD+ · 500 mg
Format
Lyophilized powder

How it works

NAD+ is an essential cellular coenzyme whose levels decline with age, which makes it a focus of aging research.

Coenzyme

The cell's currency

NAD+ shuttles electrons in energy metabolism and is required by every mitochondrion to make ATP.

Sirtuins

Fuel for repair enzymes

Sirtuins and PARP enzymes consume NAD+ to regulate DNA repair and stress responses.

Aging

Declines over time

NAD+ levels fall measurably with age in research models, one reason the coenzyme is studied in longevity science.

Key benefits

  • Longevity research focused on cellular repair and aging.
  • Energy-metabolism protocols studying how cells produce and use energy.
  • Studied as a foundational coenzyme, often part of a broader anti-aging plan.

Laboratory research only. Not for human or veterinary use.

What published research is studying

Mixed evidence base
  • Whole blood and tissue NAD+ concentrations after precursor supplementation (randomized trials)
  • Skeletal muscle insulin sensitivity in postmenopausal women with prediabetes (10-week randomized trial)
  • Systolic blood pressure and arterial stiffness in middle-aged and older adults
  • Pharmacokinetics and clearance of directly infused NAD+ in humans

Most randomized human evidence covers oral NAD+ precursors rather than NAD+ itself; the only published human infusion study was a small pharmacokinetic pilot with no clinical endpoints.

Key research findings and references

Key research findings

In an 8-week randomized placebo-controlled trial in overweight adults, the NAD+ precursor nicotinamide riboside raised whole blood NAD+ by 22%, 51% and 142% across three dose levels.

Conze D et al., Sci Rep 2019

In a 10-week randomized placebo-controlled trial in postmenopausal women with prediabetes, the NAD+ precursor nicotinamide mononucleotide increased insulin-stimulated glucose disposal.

Yoshino M et al., Science 2021 (NCT03151239)

In a 2 x 6-week randomized crossover trial in healthy middle-aged and older adults, nicotinamide riboside was well tolerated and stimulated NAD+ metabolism.

Martens CR et al., Nat Commun 2018

Published study duration

  • Intravenous NAD+ pharmacokinetic pilot: a single 6-hour infusion (Grant 2019).
  • Nicotinamide riboside dose-ranging safety trial: 8 weeks (Conze 2019).
  • Nicotinamide mononucleotide trial in prediabetes: 10 weeks (NCT03151239).

Research endpoints

  • Whole blood and plasma NAD+ concentration
  • Urinary NAD+ metabolite excretion
  • Insulin-stimulated glucose disposal by hyperinsulinaemic-euglycaemic clamp
  • Systolic blood pressure and aortic stiffness
  • Adverse event rates and tolerability

References

  1. Grant R et al., Front Aging Neurosci 2019. Changes in the human plasma and urine NAD+ metabolome during a 6 hour intravenous infusion of NAD
  2. Conze D et al., Sci Rep 2019. Safety and metabolism of long-term nicotinamide riboside chloride in healthy overweight adults
  3. Yoshino M et al., Science 2021. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
  4. Martens CR et al., Nat Commun 2018. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in middle-aged and older adults
  5. Elhassan YS et al., Cell Rep 2019. Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome

Summaries of published research, for context only. Research use only. Not for human or veterinary use.

premium-grade research peptides

NAD+500 mg

Essential cellular coenzyme, studied for cellular aging. Research compound.

Choose your vial

Choose strength
Quantity
1 vial

Add 2 more, save 5%

1 × NAD+ · 500 mg€65 / vial
€65

Free1 × 3 ml bacteriostatic water · 10 × 0.5 ml syringes · 10 × alcohol swabs · uu.life research handling card

  • €185 to free shipping
  • Ships in 1-2 business days
  • Discreet EU

What you get

  • 1 × NAD+ · 500 mg
  • Medical supply kitFreeOne kit with every vial1 × 3 ml bacteriostatic water10 × 0.5 ml syringes10 × alcohol swabs
  • uu.life research handling card

One supply kit ships with every vial: the counts above follow the quantity.

Optional spare suppliesHow To Use The Vials

The standard supplies above ship free with every vial. Add extras only if the research plan needs more.

Independently lab tested
99%+ purity standard
Identity verified by LC-MS
Batch COA available
Tracked delivery to European Union

Research bundles

Explore research bundles

Curated pairs and blends this compound is studied alongside. Priced live from the catalogue.

Research handling

Full handling guide
  1. 01

    Lyophilized, sealed, batch-numbered

    Each vial ships as a freeze-dried powder under an inert seal, tied to the batch on its Certificate of Analysis.

  2. 02

    Store cold and dark

    Unopened vials are kept refrigerated at 2-8°C away from light. Reconstituted material is stored refrigerated and used within the window the research plan defines.

  3. 03

    Reconstitute with bacteriostatic water

    The included bacteriostatic water is added slowly down the vial wall and the vial is swirled, never shaken.

  4. 04

    Research use only

    Supplied for laboratory research. Not for human or veterinary use. Handle with the personal protective equipment the laboratory requires.

Before you order

What ships in the box?

The vials selected, plus a free supply kit with every vial: one 3 ml bacteriostatic water, ten 0.5 ml syringes and ten alcohol swabs per vial, and the uu.life research handling card.

How does volume pricing work?

The price per vial depends on how many vials of the same strength are on the line. 3-4 vials take 5% off, 5 or more take 10% off. The discount is applied automatically and shows on the product page, in the cart and at checkout.

Is every batch tested?

Yes. Every batch is tested by an independent laboratory for identity and purity, and the Certificate of Analysis is linked from this page and the lab-testing library.

How fast is delivery?

Orders are typically dispatched within 1-2 business days and arrive across most of Europe in 3-5 business days, tracked, in discreet packaging. Orders over €250 ship free, and Shipping Protection can be added at checkout.

Is this for human use?

No. Every product is sold for laboratory research only and is not for human or veterinary use.

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Quality you can trace.

Batch-tested purity

Every vial ships with a Certificate of Analysis from an independent third-party lab. No exceptions.

Fast shipping

Orders are typically dispatched within 1-2 business days. Most European deliveries arrive in 3-5 business days.

Replacement guarantee

Arrived damaged? Send photos and the order number and a replacement is arranged.

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