In MMPOWER-3, a Phase 3 trial in 218 adults with primary mitochondrial myopathy, elamipretide did not improve 6-minute walk distance or total fatigue at 24 weeks.
Karaa A et al., Neurology 2023 (NCT03323749)Free shipping over €250 · Tracked, discreet delivery in Europe
premium-grade research peptides
SS-3110 mg
Lyophilized peptide · single vial
What it is
SS-31, developed under the name elamipretide, is a synthetic aromatic-cationic tetrapeptide that concentrates in the inner mitochondrial membrane. It appears in mitochondrial medicine research, including programmes in primary mitochondrial myopathy, Barth syndrome and retinal disease.
- Class
- Regenerative Peptides
- Formula
- SS-31 · 10 mg
- Format
- Lyophilized powder
How it works
SS-31 (elamipretide) is a mitochondria-targeted tetrapeptide studied in cellular energy and oxidative stress research.
Mito
Targets the inner membrane
SS-31 selectively concentrates in the inner mitochondrial membrane, where it binds the phospholipid cardiolipin.
Energy
Supports the electron chain
By stabilizing cardiolipin, the peptide is studied for its effect on electron transport efficiency and ATP production.
Oxidative
Less leakage at the source
Research models show reduced mitochondrial reactive oxygen species when cardiolipin structure is preserved.
Key benefits
- Lyophilized powder, reconstituted for repeatable preparation.
- COA-verified identity and purity, batch by batch.
- Research-use plans built around a compound-specific question.
Laboratory research only. Not for human or veterinary use.
What published research is studying
Human clinical data- Exercise capacity and fatigue in genetically confirmed primary mitochondrial myopathy (Phase 2 and Phase 3 trials)
- Walking distance and cardiac volumes in Barth syndrome (Phase 2/3 trial and open-label extension)
- Geographic atrophy growth and ellipsoid zone preservation in age-related macular degeneration (Phase 1 and Phase 2)
- Monolysocardiolipin to cardiolipin ratio as a mechanistic biomarker
Elamipretide has been through randomized Phase 2 and Phase 3 trials in rare mitochondrial disease, but the pivotal Phase 3 trial missed both of its primary endpoints.
Key research findings and references
Key research findings
In MMPOWER-2, a 30-participant randomized crossover trial, the 19.8 m difference in 6-minute walk distance missed significance, while reported fatigue improved (p = 0.0006).
Karaa A et al., J Cachexia Sarcopenia Muscle 2020In the 168-week open-label extension of TAZPOWER in Barth syndrome, 6-minute walk distance improved by a cumulative 96.1 m at week 168 (p = 0.003).
Thompson WR et al., Genet Med 2024 (NCT03098797)Published study duration
- MMPOWER-3: 24 weeks of randomized double-blind treatment in 218 participants (NCT03323749).
- MMPOWER-2 crossover: 4 weeks per period, separated by a 4-week washout (Karaa 2020).
- TAZPOWER: a 28-week randomized period followed by a 168-week open-label extension (NCT03098797).
Research endpoints
- Distance walked on the 6-minute walk test
- Primary Mitochondrial Myopathy Symptom Assessment total fatigue score
- Neuro-QoL Fatigue Short Form T score
- Three-dimensional left ventricular stroke and end-diastolic volumes
- Monolysocardiolipin to cardiolipin ratio
References
- Karaa A et al., Neurology 2023. Efficacy and safety of elamipretide in primary mitochondrial myopathy: the MMPOWER-3 randomized clinical trial
- Karaa A et al., J Cachexia Sarcopenia Muscle 2020. A randomized crossover trial of elamipretide in adults with primary mitochondrial myopathy
- Thompson WR et al., Genet Med 2024. Long-term efficacy and safety of elamipretide in Barth syndrome: 168-week open-label extension of TAZPOWER
- Ehlers JP et al., Ophthalmol Sci 2025. ReCLAIM-2: a randomized Phase II trial of elamipretide in age-related macular degeneration
- ClinicalTrials.gov NCT03323749. Phase 3 trial of elamipretide in primary mitochondrial myopathy followed by open-label extension
Summaries of published research, for context only. Research use only. Not for human or veterinary use.
premium-grade research peptides
SS-3110 mg
Choose your vial
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Quantity
1 vial
Add 2 more, save 5%
1 × SS-31 · 10 mg€69 / vial
€69
Free1 × 3 ml bacteriostatic water · 10 × 0.5 ml syringes · 10 × alcohol swabs · uu.life research handling card
- €181 to free shipping
- Ships in 1-2 business days
- Discreet EU
What you get
- 1 × SS-31 · 10 mg
Medical supply kitFreeOne kit with every vial1 × 3 ml bacteriostatic water10 × 0.5 ml syringes10 × alcohol swabs- uu.life research handling card
One supply kit ships with every vial: the counts above follow the quantity.
Optional spare suppliesHow To Use The Vials
The standard supplies above ship free with every vial. Add extras only if the research plan needs more.
Independently lab tested
99%+ purity standard
Identity verified by LC-MS
Batch COA available
Tracked delivery to European Union
Research bundles
Explore research bundles
Curated pairs and blends this compound is studied alongside. Priced live from the catalogue.
Research pairRecover bundle
BPC-157 + TB-500
The best-known recovery pairing in peptide research. Both compounds are studied for tissue repair, and they are studied together because the mechanisms differ.
Research handling
Full handling guide- 01
Lyophilized, sealed, batch-numbered
Each vial ships as a freeze-dried powder under an inert seal, tied to the batch on its Certificate of Analysis.
- 02
Store cold and dark
Unopened vials are kept refrigerated at 2-8°C away from light. Reconstituted material is stored refrigerated and used within the window the research plan defines.
- 03
Reconstitute with bacteriostatic water
The included bacteriostatic water is added slowly down the vial wall and the vial is swirled, never shaken.
- 04
Research use only
Supplied for laboratory research. Not for human or veterinary use. Handle with the personal protective equipment the laboratory requires.
Before you order
What ships in the box?
The vials selected, plus a free supply kit with every vial: one 3 ml bacteriostatic water, ten 0.5 ml syringes and ten alcohol swabs per vial, and the uu.life research handling card.
How does volume pricing work?
The price per vial depends on how many vials of the same strength are on the line. 3-4 vials take 5% off, 5 or more take 10% off. The discount is applied automatically and shows on the product page, in the cart and at checkout.
Is every batch tested?
Yes. Every batch is tested by an independent laboratory for identity and purity, and the Certificate of Analysis is linked from this page and the lab-testing library.
How fast is delivery?
Orders are typically dispatched within 1-2 business days and arrive across most of Europe in 3-5 business days, tracked, in discreet packaging. Orders over €250 ship free, and Shipping Protection can be added at checkout.
Is this for human use?
No. Every product is sold for laboratory research only and is not for human or veterinary use.
Ready to order SS-31?
Choose a strength and quantity above. Volume pricing applies automatically.
Quality you can trace.
Batch-tested purity
Every vial ships with a Certificate of Analysis from an independent third-party lab. No exceptions.
Fast shipping
Orders are typically dispatched within 1-2 business days. Most European deliveries arrive in 3-5 business days.
Replacement guarantee
Arrived damaged? Send photos and the order number and a replacement is arranged.
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