In a 56-day Phase 2 randomised, double-masked trial in 9 patients with severe dry eye, the thymosin beta-4 group showed a 35.1% greater reduction in ocular discomfort and a 59.1% greater reduction in total corneal fluorescein staining than vehicle at day 56.
Sosne G et al., Cornea 2015Free shipping over €250 · Tracked, discreet delivery in Europe
premium-grade research peptides
TB-50010 mg
The mobility peptide, researched for tissue repair and flexibility. Thymosin Beta-4 fragment, lyophilized for reconstitution.
Lyophilized peptide · single vial
What it is
TB-500 is a synthetic peptide related to thymosin beta-4, a 43-amino-acid actin-sequestering protein released by platelets at sites of injury. Thymosin beta-4 appears in research on dermal wound repair, corneal surface disease, and cardiac injury. TB-500 itself is supplied as research material and is not an approved medicine.
- Class
- Regenerative Peptides
- Formula
- TB-500 · 10 mg
- Format
- Lyophilized powder
How it works
TB-500 is a synthetic fragment of thymosin beta-4, a naturally occurring peptide researched for tissue repair and flexibility.
Actin
Binds the cell's scaffold
Thymosin beta-4 binds actin, the structural protein that governs how cells move and change shape.
Migration
Moves repair cells
TB-500 is studied for promoting cell migration, the step that carries repair cells toward damaged tissue.
Flexibility
Researched for mobility
Preclinical models examine the fragment for tissue flexibility and reduced adhesion formation after injury.
Key benefits
- Recovery research focused on soft tissue, mobility, and flexibility.
- Training-recovery protocols after heavy load or injury.
- Commonly paired with BPC-157 for a fuller recovery stack.
Laboratory research only. Not for human or veterinary use.
What published research is studying
Mixed evidence base- Dermal wound healing in rodent full-thickness wound models
- Severe dry eye disease and corneal epithelial repair (Phase 2 and Phase 3 trials)
- Pressure ulcers and venous stasis ulcers (Phase 2 trials)
- Cardiomyocyte survival and cardiac repair after coronary artery ligation (preclinical)
Human trials exist for full-length thymosin beta-4 in dry eye and chronic wounds, several of them small, while the shorter TB-500 fragment sold as research material has no published human trials of its own.
Key research findings and references
Key research findings
In a rat full-thickness wound model, thymosin beta-4 increased re-epithelialisation by 42% at 4 days and by as much as 61% at 7 days compared with saline controls, with greater wound contraction and collagen deposition.
Malinda KM et al., J Invest Dermatol 1999After coronary artery ligation in mice, thymosin beta-4 upregulated integrin-linked kinase and Akt activity in the heart, enhanced early myocyte survival, and improved cardiac function.
Bock-Marquette I et al., Nature 2004A review of two Phase 2 trials in stasis and pressure ulcers reported that, among patients whose ulcers healed, healing was accelerated by almost a month relative to control.
Treadwell T et al., Ann N Y Acad Sci 2012Published study duration
- Phase 2 severe dry eye trial: 28 days of dosing with follow-up through day 56 (NCT01393132).
- Phase 2 pressure ulcer study: safety and tolerability assessed over up to 84 days (NCT00382174).
- Rat full-thickness wound model: re-epithelialisation measured at 4 and 7 days after wounding (Malinda et al., 1999).
Research endpoints
- Ocular discomfort score (OSDI questionnaire)
- Corneal fluorescein staining (NEI grading)
- Tear film breakup time and tear volume
- Rate of re-epithelialisation and wound contraction
- Cardiac function after coronary ligation
References
- Sosne G et al., Cornea 2015. Thymosin beta-4 significantly improves signs and symptoms of severe dry eye in a phase 2 randomized trial
- Malinda KM et al., J Invest Dermatol 1999. Thymosin beta-4 accelerates wound healing
- Bock-Marquette I et al., Nature 2004. Thymosin beta-4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
- Treadwell T et al., Ann N Y Acad Sci 2012. The regenerative peptide thymosin beta-4 accelerates the rate of dermal healing
- NCT01393132. Phase 2 study of thymosin beta 4 eye drops versus vehicle in severe dry eye
- NCT00382174. Phase 2 dose-response study of thymosin beta 4 in patients with pressure ulcers
Summaries of published research, for context only. Research use only. Not for human or veterinary use.
premium-grade research peptides
TB-50010 mg
The mobility peptide, researched for tissue repair and flexibility. Thymosin Beta-4 fragment, lyophilized for reconstitution.
Choose your vial
Choose strength
Quantity
1 vial
Add 2 more, save 5%
1 × TB-500 · 10 mg€89 / vial
€89
Free1 × 3 ml bacteriostatic water · 10 × 0.5 ml syringes · 10 × alcohol swabs · uu.life research handling card
- €161 to free shipping
- Ships in 1-2 business days
- Discreet EU
What you get
- 1 × TB-500 · 10 mg
Medical supply kitFreeOne kit with every vial1 × 3 ml bacteriostatic water10 × 0.5 ml syringes10 × alcohol swabs- uu.life research handling card
One supply kit ships with every vial: the counts above follow the quantity.
Optional spare suppliesHow To Use The Vials
The standard supplies above ship free with every vial. Add extras only if the research plan needs more.
Independently lab tested
99%+ purity standard
Identity verified by LC-MS
Batch COA available
Tracked delivery to European Union
Research bundles
Explore research bundles
Curated pairs and blends this compound is studied alongside. Priced live from the catalogue.
Research pairRecover bundle
BPC-157 + TB-500
The best-known recovery pairing in peptide research. Both compounds are studied for tissue repair, and they are studied together because the mechanisms differ.
Single-vial blendWolverine
BPC-157 + TB-500
Single-vial blendGlow
GHK-Cu + TB-500 + BPC-157
Research handling
Full handling guide- 01
Lyophilized, sealed, batch-numbered
Each vial ships as a freeze-dried powder under an inert seal, tied to the batch on its Certificate of Analysis.
- 02
Store cold and dark
Unopened vials are kept refrigerated at 2-8°C away from light. Reconstituted material is stored refrigerated and used within the window the research plan defines.
- 03
Reconstitute with bacteriostatic water
The included bacteriostatic water is added slowly down the vial wall and the vial is swirled, never shaken.
- 04
Research use only
Supplied for laboratory research. Not for human or veterinary use. Handle with the personal protective equipment the laboratory requires.
Before you order
What ships in the box?
The vials selected, plus a free supply kit with every vial: one 3 ml bacteriostatic water, ten 0.5 ml syringes and ten alcohol swabs per vial, and the uu.life research handling card.
How does volume pricing work?
The price per vial depends on how many vials of the same strength are on the line. 3-4 vials take 5% off, 5 or more take 10% off. The discount is applied automatically and shows on the product page, in the cart and at checkout.
Is every batch tested?
Yes. Every batch is tested by an independent laboratory for identity and purity, and the Certificate of Analysis is linked from this page and the lab-testing library.
How fast is delivery?
Orders are typically dispatched within 1-2 business days and arrive across most of Europe in 3-5 business days, tracked, in discreet packaging. Orders over €250 ship free, and Shipping Protection can be added at checkout.
Is this for human use?
No. Every product is sold for laboratory research only and is not for human or veterinary use.
Ready to order TB-500?
Choose a strength and quantity above. Volume pricing applies automatically.
Quality you can trace.
Batch-tested purity
Every vial ships with a Certificate of Analysis from an independent third-party lab. No exceptions.
Fast shipping
Orders are typically dispatched within 1-2 business days. Most European deliveries arrive in 3-5 business days.
Replacement guarantee
Arrived damaged? Send photos and the order number and a replacement is arranged.
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