In human intestinal epithelial and T cell lines, nanomolar KPV inhibited NF-kappaB and MAP kinase activation, and oral KPV reduced the incidence of DSS- and TNBS-induced colitis in mice alongside lower pro-inflammatory cytokine expression.
Dalmasso G et al., Gastroenterology 2008Free shipping over €250 · Tracked, discreet delivery in Europe
premium-grade research peptides
KPV10 mg
Anti-inflammatory gut health premium-grade research peptide. Lyophilized powder for reconstitution.
Lyophilized peptide · single vial
What it is
KPV is a tripeptide of lysine, proline, and valine, corresponding to the C-terminal fragment 11-13 of alpha-melanocyte-stimulating hormone. It appears in preclinical research on intestinal inflammation and epithelial barrier biology. It is not an approved medicine.
- Class
- Regenerative Peptides
- Formula
- KPV · 10 mg
- Format
- Lyophilized powder
How it works
KPV is a three-amino-acid fragment of alpha-MSH, researched for anti-inflammatory effects, especially in gut models.
Alpha-MSH
A hormone fragment
KPV is the terminal tripeptide of alpha-MSH, carrying the parent hormone's anti-inflammatory activity without its pigment effects.
Gut
Studied in the intestine
Research models of intestinal inflammation examine KPV for calming immune signaling in the gut lining.
Transport
Carried into cells
KPV is small enough to be taken up by peptide transporters, a property studied for oral and local delivery.
Key benefits
- Gut-support research focused on barrier integrity and comfort.
- Recovery protocols studying how it calms the inflammatory response.
- Often researched as a gut-focused companion to broader recovery work.
Laboratory research only. Not for human or veterinary use.
What published research is studying
Preclinical research- Intestinal inflammation in DSS and TNBS mouse colitis models
- PepT1-mediated transport of the peptide into epithelial and immune cells
- Mucosal healing and pro-inflammatory cytokine expression in ulcerative colitis models
- Colon-targeted oral and nanoparticle delivery routes
All published findings come from cell-culture work and mouse colitis models, and a search of ClinicalTrials.gov returns no registered human trials of KPV.
Key research findings and references
Key research findings
In DSS colitis and CD45RB-high transfer colitis in mice, KPV produced earlier recovery, significantly stronger regain of body weight, and significantly reduced inflammatory infiltrate and colonic myeloperoxidase activity.
Kannengiesser K et al., Inflamm Bowel Dis 2008KPV loaded into hyaluronic-acid-functionalised nanoparticles and delivered orally in a hydrogel reduced mucosal damage and downregulated TNF-alpha in a mouse ulcerative colitis model, more so than non-targeted nanoparticles.
Xiao B et al., Mol Ther 2017Published study duration
- Murine DSS colitis model: colonic inflammation assessed 8 days after DSS treatment (Dalmasso et al., Gastroenterology 2008).
- Murine TNBS colitis model: colonic inflammation assessed 48 hours after induction (Dalmasso et al., Gastroenterology 2008).
Research endpoints
- Myeloperoxidase activity in colonic tissue
- Histological inflammatory cell infiltrate
- Body-weight change during colitis
- Pro-inflammatory cytokine mRNA expression
- NF-kappaB and MAP kinase activation in vitro
References
- Dalmasso G et al., Gastroenterology 2008. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation
- Kannengiesser K et al., Inflamm Bowel Dis 2008. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease
- Xiao B et al., Mol Ther 2017. Orally targeted delivery of tripeptide KPV via hyaluronic acid-functionalized nanoparticles
- Dalmasso G et al., Gastroenterology 2008 (full text, PMC)
Summaries of published research, for context only. Research use only. Not for human or veterinary use.
premium-grade research peptides
KPV10 mg
Anti-inflammatory gut health premium-grade research peptide. Lyophilized powder for reconstitution.
Choose your vial
Choose strength
Quantity
1 vial
Add 2 more, save 5%
1 × KPV · 10 mg€65 / vial
€65
Free1 × 3 ml bacteriostatic water · 10 × 0.5 ml syringes · 10 × alcohol swabs · uu.life research handling card
- €185 to free shipping
- Ships in 1-2 business days
- Discreet EU
What you get
- 1 × KPV · 10 mg
Medical supply kitFreeOne kit with every vial1 × 3 ml bacteriostatic water10 × 0.5 ml syringes10 × alcohol swabs- uu.life research handling card
One supply kit ships with every vial: the counts above follow the quantity.
Optional spare suppliesHow To Use The Vials
The standard supplies above ship free with every vial. Add extras only if the research plan needs more.
Independently lab tested
99%+ purity standard
Identity verified by LC-MS
Batch COA available
Tracked delivery to European Union
Research bundles
Explore research bundles
Curated pairs and blends this compound is studied alongside. Priced live from the catalogue.
Research pairRecover bundle
BPC-157 + TB-500
The best-known recovery pairing in peptide research. Both compounds are studied for tissue repair, and they are studied together because the mechanisms differ.
Research handling
Full handling guide- 01
Lyophilized, sealed, batch-numbered
Each vial ships as a freeze-dried powder under an inert seal, tied to the batch on its Certificate of Analysis.
- 02
Store cold and dark
Unopened vials are kept refrigerated at 2-8°C away from light. Reconstituted material is stored refrigerated and used within the window the research plan defines.
- 03
Reconstitute with bacteriostatic water
The included bacteriostatic water is added slowly down the vial wall and the vial is swirled, never shaken.
- 04
Research use only
Supplied for laboratory research. Not for human or veterinary use. Handle with the personal protective equipment the laboratory requires.
Before you order
What ships in the box?
The vials selected, plus a free supply kit with every vial: one 3 ml bacteriostatic water, ten 0.5 ml syringes and ten alcohol swabs per vial, and the uu.life research handling card.
How does volume pricing work?
The price per vial depends on how many vials of the same strength are on the line. 3-4 vials take 5% off, 5 or more take 10% off. The discount is applied automatically and shows on the product page, in the cart and at checkout.
Is every batch tested?
Yes. Every batch is tested by an independent laboratory for identity and purity, and the Certificate of Analysis is linked from this page and the lab-testing library.
How fast is delivery?
Orders are typically dispatched within 1-2 business days and arrive across most of Europe in 3-5 business days, tracked, in discreet packaging. Orders over €250 ship free, and Shipping Protection can be added at checkout.
Is this for human use?
No. Every product is sold for laboratory research only and is not for human or veterinary use.
Ready to order KPV?
Choose a strength and quantity above. Volume pricing applies automatically.
Quality you can trace.
Batch-tested purity
Every vial ships with a Certificate of Analysis from an independent third-party lab. No exceptions.
Fast shipping
Orders are typically dispatched within 1-2 business days. Most European deliveries arrive in 3-5 business days.
Replacement guarantee
Arrived damaged? Send photos and the order number and a replacement is arranged.
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